Psychological progress in 1905.

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Progress and limitations in the psychological study of craniofacial anomalies.

The term "craniofacial anomalies" (CFAs) refers to a diverse group of congenital disorders including complex syndromes marked by multiple sutural fusions (e.g., Crouzan's, Treacher Collins, and Aperts syndromes), simple craniosynostoses involving single fusions (e.g., sagittal synostosis), hemifacial microsomia, clefts of the lip and/or palate, and isolated "birth marks" on the face and neck, s...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

Mark's Annual Reports, 1905